Perphenazine is medicine to treat schizophrenic symptoms (schizophrenia).The use of this drug will help sufferers schizophrenia to be able to think more clearly, reduce anxiety, hallucinations, and aggressive behavior.
Apart from being an antipsychotic, perphenazine is also sometimes used to relieve severe nausea. Perphenazine works by balancing the brain's natural chemicals, such as dopamine. With more balanced levels of chemicals in the brain, the symptoms of schizophrenia can be reduced.
Please note that this drug should not be used to treat psychosis or mental disorders due to dementia.
Perphenazine trademark: trilaphone
What is Perphenazine
| group | Prescription drugs |
| Category | Phenothiazine type antipsychotics |
| Benefit | Relieves the symptoms of schizophrenia |
| Consumed by | Mature |
| Perphenazine for pregnant and lactating women | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. However, some studies have shown an increased risk of respiratory distress, excessive sleepiness, impaired muscle tone, or tremors if the fetus is exposed to perphenazine since the third trimester of pregnancy. Perphenazine may be absorbed into breast milk. If you are breastfeeding, do not use this medicine before consulting your doctor. |
| Shape | Tablet |
Warnings Before Taking Perphenazine
Perphenazine should only be taken according to a doctor's prescription. Note the following points before taking perphenazine:
- Do not take this medicine if you are allergic to perphenazine or to phenothiazines, such as chlorpromazine, fluphenazine, prochlorperazine, promethazine, or thioridazine.
- Tell your doctor if you have liver disease, heart disease, bone marrow disorders, blood disorders, or alcoholism.
- Tell your doctor if you have or have had major depression, hypertension, Parkinson's disease, seizures, kidney disease, adrenal gland tumors, glaucoma, hypocalcemia, or a lung disease, such as asthma or emphysema.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Do not drive a vehicle or do activities that require alertness after taking perphenazine, as this medicine may cause dizziness, drowsiness, or blurred vision.
- Avoid prolonged exposure to the sun while taking perphenazine, as this drug can make the skin more sensitive to sunlight.
- Tell your doctor that you are taking perphenazine if you plan to have any surgery, including dental surgery.
- See your doctor immediately if you have an allergic drug reaction, serious side effect, or overdose after taking perphenazine.
Dosage and Rules for Use of Perphenazine
The dose of perphenazine will be adjusted according to the patient's response to the drug, the condition, and the severity of the condition. The following are common doses of perphenazine for adults:
Condition: Schizophrenia
- For outpatients, the initial dose is 4–8 mg, 3 times daily. The maximum dose is 24 mg per day.
- For hospitalized patients, the initial dose is 8–16 mg, 2–4 times daily. The maximum dose is 64 mg per day.
Condition: Severe nausea and vomiting
- The dose is 8-16 mg per day which is divided into several consumption schedules. The maximum dose is 24 mg.
How to Take Perphenazine Correctly
Take perphenazine according to the doctor's instructions and the instructions on the medicine package. Do not increase or decrease the dose of the drug without consulting your doctor first.
Perphenazine tablets need to be taken with food or immediately after a meal. Take the medicine at the same time every day for effective treatment.
Do not stop taking this drug suddenly because it can increase the risk of your symptoms getting worse. The doctor will reduce the dose of the drug gradually until the patient can safely stop taking the drug.
If you forget to take perphenazine, take it immediately if the break with the next consumption schedule is not too close. If it is close, ignore it and do not double the next dose.
To prevent dizziness after taking this medicine, get up from a sitting or lying position slowly.
Store perphenazine in a closed container in a cool, dry place. Keep the drug away from direct sunlight. Keep this medicine out of reach of children.
InteractionPerphenazine with Other Drugs
Some of the effects of drug interactions that can occur if perphenazine is used with certain drugs are:
- Decreased effectiveness of epinephrine
- Enhanced anticholinergic effect when used with atropine
- Increased blood levels of perphenazine when used with tricyclic antidepressants or selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, paroxetine, or sertraline
- Increased risk of cardiac QT prolongation if used with disopyramide, ibutilide, indapamide, pentamidine, pimozide, procainamide, quinidine, or sotalol
- Increased risk of side effects, such as low blood pressure, when used with antihistamine or barbiturate medications
Side Effects and Dangers of Perphenazine
Side effects that can occur after taking perphenazine include:
- Drowsiness
- Dizzy
- Feeling like you're going to faint
- dry mouth
- Blurred vision
- Fatigue
- Constipation
- Drastic weight gain
Check with your doctor if the side effects above don't go away or get worse. Call your doctor right away if you have an allergic reaction to a drug or serious side effects, such as:
- Tardive dyskinesia, which is characterized by repetitive and involuntary muscle movements, such as sticking out the tongue or moving the fingers or toes
- Increased prolactin hormone in women, which is characterized by the release of breast milk when not pregnant or breastfeeding, cessation of the menstrual cycle, and difficulty getting pregnant
- Increased prolactin hormone in men, which is characterized by breast enlargement, decreased sexual desire, and the inability to produce sperm
- Neuroleptic malignant syndrome (NMS), which is characterized by fever, muscle pain, weakness, or stiffness, cloudy urine, excessive tiredness, or excessive sweating
- Easy bruising or bleeding, slow, fast, or irregular heartbeat, jaundice, fainting, or seizures
