Phenylbutazone is a drug to treat pain and inflammation in rheumatism, gout, or osteoarthritis. This medicine should only be used according to a doctor's prescription.
Phenylbutazone is a non-steroidal anti-inflammatory drug. This drug has anti-inflammatory, anti-fever, and anti-pain effects, which work by decreasing the production of prostaglandins.
When there is injury or damage to the body, the prostaglandins produced will trigger an inflammatory reaction so that swelling and pain appear. By inhibiting the production of prostaglandins, pain and other inflammatory symptoms can subside.
Phenylbutazone trademark: Rheumakap
What is Phenylbutazone
| group | Prescription drugs |
| Category | Non-steroidal anti-inflammatory drugs (NSAIDs) |
| Benefit | Reduce pain and inflammation due to rheumatism or gout |
| Consumed by | Mature |
| Phenylbutazone for pregnant and lactating women | Category C:Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. Category D (in the third trimester and close to delivery): There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations. It is not known whether phenylbutazone is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Film-coated capsules |
Precautions Before Taking Phenylbutazone
Phenylbutazone should not be used carelessly. The following are things you should pay attention to before taking phenibutazone:
- Do not use this medication if you are allergic to phenylbutazone or NSAIDs. Tell your doctor about any allergies you have.
- Tell your doctor if you have or have had asthma, diabetes, heart disease, hypertension, thyroid disease, kidney problems, colitis, liver problems, stomach ulcers, breathing problems, Sjogren's syndrome, intestinal ulcers, blood clotting disorders, diabetes, or thrombocytopenia .
- Tell your doctor if you have or have ever had gastrointestinal bleeding or have had any procedures bypass heart. Phenylbutazone should not be used under these conditions.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you are taking certain medications, supplements or herbal products,
- See your doctor right away if you experience an allergic drug reaction, overdose, or serious side effect after taking phenylbutazone.
Dosage and Instructions for Use of Phenylbutazone
Phenylbutazone should only be used as prescribed by a doctor. The following are general doses of phenylbutazone for adults based on the condition to be treated:
- Condition: rheumatism
Doses can be given up to 600 mg per day, divided into several consumption schedules. The dose can be reduced after 1-3 days of treatment. Maximum treatment time is 1 week.
- Condition: Gout (gout)
Doses can be given up to 800 mg per day, according to the patient's needs. The dose can be reduced after 1-3 days of treatment. Maximum treatment time is 1 week.
How to Take Phenylbutazone Correctly
Always follow your doctor's advice and read the instructions on the medicine package before taking phenylbutazone. Do not increase or decrease the dose without consulting your doctor first.
Phenylbutazone is taken after meals. Swallow the phenylbutazone caplet whole with the help of a glass of water. Do not chew or crush the medicine as this may affect the effectiveness of the medicine.
Take phenylbutazone at the same time each day. If you forget to take phenylbutazone, do it as soon as you remember if the interval between the next consumption is not too close. If it is close, ignore it and do not double the dose.
Store phenylbutazone in a closed container, in a dry place, at room temperature, and away from direct sunlight. Keep medicine out of reach of children.
Phenylbutazone Interactions with Other Drugs
The following are the effects of interactions that may occur if phenylbutazone is used together with other medicines:
- Decreased phenytoin metabolism
- Reduced discharge of methotrexate
- Increased risk of kidney damage when used with adefovir, tacrolimus, or intravenous immunoglobulin
- Increased risk of bleeding if used with anticoagulant drugs, such as warfarin or apixaban
- Increased risk of bone marrow dysfunction when used with clozapine
- Increased risk of gastrointestinal disturbances, including inflammation, bleeding, injury, and even tearing (perforation), when used with ketorolac
- Increased levels of lithium in the blood are at risk of causing lithium poisoning
Phenylbutazone Side Effects and Dangers
There are several side effects that can occur after taking phenylbutazone, including:
- Stomach pain or vomiting
- Heartburn
- Diarrhea or constipation
- bloating
- Dizzy
- Drowsiness
- Weak
Consult a doctor if these side effects do not improve or even get worse. Call your doctor right away if you have an allergic reaction to a drug or serious side effects, such as:
- There is blood in the stool or black stool
- Little amount of urine or infrequent urination
- Yellow skin and whites of the eyes
- Hypertension
- Chest pain
- Difficulty speaking
- Visual disturbance
- Ears ringing
- Numbness or tingling
In addition, the use of phenylbutazone can also cause bone marrow damage that causes low white blood cell counts.
