Parnaparin - Benefits, dosage and side effects

Parnaparin is an anticoagulant drug used to prevent and treat thrombophlebitis, includingdeep vein thrombosis. This drug is a type of low molecular weight heparin (LMWH) which has an antithrombotic effect.

Parnaparin can prevent deep vein thrombosis (DVT) postoperatively and treat other thromboembolic disease or disorders. Parnaparin should be given by injection subcutaneously (through the layer under the skin) and should not be administered intramuscularly (directly into the muscle).

Parnaparin is available in an injectable form that can only be given by a doctor. During the use of parnaparin, periodic complete blood counts should be performed.

Parnaparin trademark: Fluxum

What is Parnaparin?

CategoryPrescription drugs
BenefitPrevent deep vein thrombosis postoperatively and treat thromboembolic disorders or diseases
Used byMature
Parnaparin for pregnant and lactating womenCategory C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether Parnaparin is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug formInject

Precautions Before Using Parnaparin:

  • Do not use parnaparin if you have a history of allergy to this drug.
  • Do not use parnaparin if you have a history of thrombocytopenia after taking heparin, acute bacterial endocarditis, hemorrhagic stroke, and other conditions or diseases that pose a risk of bleeding.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you have a history of kidney disease, liver disease, obesity, hypertension, and other conditions or diseases that put you at risk of bleeding.
  • Tell your doctor if you have had brain or spinal cord surgery, spinal anesthesia or analgesia, therapy with antivitamin K, or received a prosthetic heart valve.
  • Avoid consuming alcoholic beverages while taking parnaparin because it can increase the risk of bleeding.
  • Avoid smoking while using parnaparin because it can decrease the effectiveness of the drug.
  • Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
  • See your doctor immediately if you have an allergic reaction or overdose after taking parnaparin.

Dosage and Rules for Use of Parnaparin

Parnaparin should only be given to adults, with a note that its use in elderly patients needs more attention. The dose of parnaparin will be determined by the doctor according to the patient's condition.

Here is the recommended dosage division:

Condition: Prophylaxis deep vein thrombosis (DVT) postoperative

  • General surgery: 3,200 IU 2 hours before surgery, continued for 7 days or until the patient is fully recovered
  • Orthopedic or high-risk surgery: 4,250 IU mL 12 hours before and 12 hours after surgery, continued for 10 days

Condition: Thromboembolic disorders

  • Dose: 6,400 IU for 7–10 days

How to Use Parnaparin Correctly

Follow the doctor's advice in using parnaparin. Parnaparin is only available in injectable form. Therefore, this drug should only be given by a doctor or medical officer under the supervision of a doctor in a hospital.

Parnaparin must be injected subcutaneously. Injections are usually performed alternately on the fatty tissue in the upper right or left buttocks, or abdominal circumference.

Perform a complete blood count routinely while using parnaparin. Generally, the examination needs to be done 2 times a week for at least 1 month. After that, the frequency of inspections can be reduced.

Store parnaparin in a cool place, and keep out of reach of children.

Interaction of Parnaparin with Other Drugs and Ingredients

When used with other medicines, parnaparin can cause a number of interactions, including:

  • Increased risk of side effects such as bleeding if used with other anticoagulants, antiplatelet drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), or fibrinolytic drugs, such as streptokinase
  • Increased risk of hyperkalemia when used with ACE inhibitors
  • Decreased effectiveness of parnaparin when used with nitroglycerin by intravenous injection

Side Effects and Dangers of Parnaparin

Some of the side effects that often arise from taking parnaparin are:

  • Bleeding
  • Low platelet count (thrombocytopenia)
  • Tissue damage or death at the injection site
  • Hyperkalemia associated with hyperaldosteronism
  • Increased transaminases . enzymes

Check with your doctor if you experience any of the side effects mentioned above or experience a drug reaction, such as an itchy and swollen rash, swollen eyes and lips, or difficulty breathing, after using parnaparin.