Pancuronium is a drug used to relax muscles during endotracheal intubation procedures or during surgery. Pancuronium is a non-depolarizing muscle relaxant that works by blocking motor nerve excitatory signals to muscles.
Pancuronium is used in the process of anesthesia or anesthesia. This drug will be given intravenously or through a vein. This medicine will be injected by a doctor or by a medical officer under the supervision of a doctor.
Trademark pancuronium: Pavulon
What is Pancuronium?
| group | Neuromuscular blocking drugs (NMBDs) or nondepolarizing muscle relaxants |
| Category | Prescription drugs |
| Benefit | Relax muscles during endotracheal intubation or during surgery |
| Used by | Adults and children |
| Pancuronium for pregnant and lactating women | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. It is not known whether Pancuronium is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Inject |
Precautions Before Using Pancuronium:
- Do not use pancuronium if you have a history of allergy to this drug.
- Do not take pancururonium with other muscle relaxants, such as suxamethonium.
- Tell your doctor if you have liver disease, kidney disease, disorders of the respiratory tract and lungs, heart disease, hypertension, nerve and muscle (neuromuscular) disorders, including muscular dystrophy, myasthenia gravis, or polio.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
- Tell your doctor if you are planning any surgery, including dental surgery.
- See your doctor right away if you have an allergic reaction or overdose after using this medicine.
Dosage and Rules for Use of Pancuronium
Pancuronium is given by injection into a vein (intravenous) by a doctor or medical officer under the supervision of a doctor. Below is the division of pancuronium dosage based on its intended use:
As part of an anesthetic procedure
- Mature: 0.04–0.1 mg/kgBW.
Maintenance dose: 0.015–0.1 mg/kgBW
- Children <30 days old: 0.02 mg/kgBB
Maintenance dose: 0.05–0.1 mg/kgBW
- Children >30 days old: 0.04–0.1 mg/kgBW
Maintenance dose: 0.015–0.1 mg/kgBW
Endotracheal intubation procedure
- Mature: 0.06–0.1 mg/kgBW
- Children <30 days old: 0.06–0.1 mg/kgBW
Intensive care for patients on ventilator
- Mature: 0.06 mg/kg, every 1–1½ hours
How to Use Pancuronium Correctly
Pancuronium is used by injection into a vein (intravenous) or through an IV. Therefore, this medicine should only be given by a doctor or medical worker under the supervision of a doctor.
Do not try to use pancuronium without a doctor's supervision. This will endanger lives.
This medicine should be stored at room temperature. Avoid exposure to direct sunlight and keep out of reach of children.
Interactions of Pancuronium with Other Drugs
There are several interactions that can occur if pancuronium is used with other medicines, including:
- Increased effectiveness of pancuronium and risk of side effects when used with aminoglycoside antibiotics, polypeptide antibiotics, fentanyl, amphotericin B, quinine, or other muscle relaxants, such as suxamethonium
- Increased risk of prolonged effects of pancuronium when used with colistimethate or inhalational anesthetic drugs, such as halothane and enflurane
- Increased risk of side effects, such as muscle weakness, paralysis, and difficulty breathing, when used with abobotulinumtoxinA, incobotulinumtoxin A, onabotulinumtoxinA, or prabotulinumtoxinA
- Altered effect of pancuronium and increased risk of myopathy when used concomitantly with corticosteroid drugs
- Decreased effectiveness of pancuronium when used with neostigmine, theophylline, or azathioprine
Side Effects and Dangers of Pancuronium
Some of the side effects that can appear after using pancuronium are:
- Increased blood pressure to hypertension
- Increased heart rate (tachycardia)
- Narrowing of the bronchial tubes (bronchospasm)
- Increased production and secretion of saliva
- Pain or sores at the injection site
In some cases, the use of pancuronium can also cause a drop in blood pressure (hypotension) and bradycardia.
See a doctor immediately if you have any of the above-mentioned complaints or side effects or you have an allergic reaction to the drug, which is characterized by an itchy rash on the skin, swelling of the eyelids and lips, or difficulty breathing.
