Cisplatin is chemotherapy drugs used to treatcertain types of cancer, such as cancer ovarian, testicular cancer, or cancer bladder. This drug can be used alone or in combination with other anticancer drugs.
Cisplatin is a chemotherapy drug that contains platinum. This drug works by inhibiting the formation of cell DNA so that it can slow down and stop the growth of cancer cells.
cisplatin trademark: Cilatin 50, Cisteen, Cisplasan, Cisplatin, Platol
What is Cisplatin
| group | Prescription drugs |
| Category | Chemotherapy drugs |
| Benefit | Treat ovarian cancer, testicular cancer, and bladder cancer |
| Used by | Adults and children |
| Cisplatin for Pregnant and Breastfeeding Mothers | Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations. Cisplatin can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor. |
| Medicine Form | Inject through infusion |
Precautions Before Using Cisplatin
The following are some things you need to pay attention to before using cisplatin:
- Tell your doctor about any allergies you have. Cisplatin should not be used by patients who are allergic to this drug.
- Tell your doctor if you have or have ever had kidney disease, hearing loss, gout, tingling, anemia, low white blood cell count (leukopenia), thrombocytopenia, or electrolyte imbalance, such as salt deficiency, hypokalemia, or hypomagnesemia.
- Tell your doctor if you are having radiotherapy or are taking any other medicines, including supplements or herbal products.
- Tell your doctor that you are taking cisplatin before undergoing certain medical procedures or surgery.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy. Use effective contraception during treatment with cisplatin for up to 11–14 months afterward.
- As much as possible, avoid close contact with people with infectious diseases that are easily transmitted, such as the flu, because they can increase your risk of contracting it.
- Tell your doctor if you plan to get vaccinated while on treatment with cisplatin.
- See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose, after using cisplatin.
Dosage and Instructions for Use of Cisplatin
The dose of cisplatin given will be adjusted according to the condition being treated and the age of the patient. The following is a breakdown of the general dosage of cisplatin given by intravenous infusion (intravenous/IV) for adult patients:
Condition: Ovarian cancer that has spread (metastasized)
- The dose is 75–100 mg/m2 body surface area (LPT) per cycle, every 4 weeks. This drug will be combined with cyclophosphamide.
Condition: Testicular cancer that has spread
- The dose is 20 mg/m2 LPT for 5 days per cycle. The dose will be repeated every 3 weeks. The drug will be combined with bleomycin and etoposide.
Condition: Advanced bladder cancer
- The dose is 50–70 mg/m2 LPT per cycle, every 3–4 weeks, the dose will be adjusted according to the radiotherapy or chemotherapy that has been undertaken.
How to Use Cisplatin Correctly
Cisplatin will be given by a doctor or medical officer under the supervision of a doctor. This drug will be given into a vein, for 6-8 hours. Always follow the doctor's advice while undergoing treatment with this medicine.
Drink plenty of water while taking cisplatin to prevent kidney damage from taking cisplatin. Tell your doctor immediately if cisplatin leaks into the skin. Cisplatin can injure the skin that is exposed to the drug.
During treatment with cisplatin, your doctor will ask you to have regular blood tests to check kidney function, liver function, and blood cell counts.
Your doctor may also order other tests, such as hearing tests, to monitor your condition and your response to medications. Do not stop treatment without consulting your doctor first.
Cisplatin Interactions with Other Drugs
Drug interactions that can occur if cisplatin is used with certain drugs include:
- Decreased therapeutic effect of cisplatin when used with pyridoxine
- Decreased effectiveness of influenza vaccine trivalent or influenza vaccine quadrivalent
- Increased risk of infection when used with tofacitinib
- Increased blood levels of cisplatin when used with tafenoquine or trilaciclib
- Increased risk of cisplatin poisoning when used with palifermin
- Increased risk of developing kidney or ear damage if used with amphotericin B, cidofovir, or bacitracin
Cisplatin Side Effects and Dangers
There are several side effects that can arise after using cisplatin, namely:
- Nausea or vomiting
- Loss of appetite
- Diarrhea
- Loss of the ability of the sense of taste to taste the food or drink consumed
- Hair loss
Tell your doctor if the above side effects do not improve or get worse. See your doctor right away if you have an allergic reaction or serious side effects, such as:
- Easy bruising, nosebleeds that are getting more frequent and difficult to stop, or bleeding gums
- Pain, redness, or swelling at the area of the skin that was injected
- Pain behind the eye, blurry vision, or blindness
- Headaches, seizures, or other mental or mood disturbances,
- Chest pain or swelling, pain, and redness in the legs
- Hearing loss, which can be characterized by symptoms such as tinnitus, sudden deafness, or difficulty hearing high-pitched sounds
- Impaired kidney function which can be characterized by symptoms such as swelling in the legs, very little amount of urine, or infrequent urination
- Infectious disease due to low white blood cell count which can be characterized by symptoms such as sore throat, fever, cough, or thrush
- Disorders of nervous system function that can be characterized by symptoms such as reduced reflexes, the appearance of burning, tingling, or numbness in the feet and hands
