Isosorbide mononitrate orisosorbide mononitrate is medicineto prevent and treat chest pain due to coronary heart disease. In addition, isosorbide mononitrateIt can also be used as an adjunct drug in the treatment of heart failure.
Isosorbide mononitrate is a nitrate class of drugs that works by relaxing blood vessel muscles. That way, blood vessels can widen and blood flow can be smoother. This way of working will also lower blood pressure.
Isosorbide mononitrate trademarks:Cardismo, Cardismo XR, Imdur, Monecto 20
What is Isosorbide Mononitrate
| group | Prescription drugs |
| Category | Nitrate |
| Benefit | Prevent and treat angina pectoris and as adjunctive therapy for patients with heart failure |
| Consumed by | Mature |
| Isosorbide mononitrate for pregnant and lactating women | CategoryC: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. It is not known whether isosorbide mononitrate is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without telling your doctor. |
| Drug form | Tablets, slow-release tablets |
Precautions Before Taking Isosorbide Mononitrate
Isosorbide mononitrate should only be used as prescribed by a doctor. The following are things you need to pay attention to before taking isosorbide mononitrate:
- Tell your doctor about any allergies you have. Isosorbide mononitrate should not be used by patients who are allergic to this drug or to other nitrate drugs, such as nitroglycerin.
- Do not take isosorbide mononitrate if you are taking riociguat and class drugs phosphodiesterase inhibitor type 5 (PDE5), such as sildenafil.
- Tell your doctor if you have or have had congestive heart failure, kidney disease, liver disease, hypotension, hypoxemia, hyperthyroidism, glaucoma, anemia, head injury, or heart attack.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you are taking any other medicines, including supplements, or herbal products.
- Tell your doctor that you are being treated with isosorbide mononitrate if you are planning to have any surgery, including dental surgery.
- See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after taking isosorbide mononitrate.
Dosage and Instructions for Use of Isosorbide Mononitrate
The dose of isosorbide mononitrate will be determined based on the patient's age, condition, and body response to the drug. The following are doses of isosorbide mononitrate for adults based on their intended use:
Purpose: Prevent angina pectoris
- Dosage of fast-release tablets 20 mg, 2-3 times a day.
- Dosage of 30–60 mg slow-release tablets, once a day, is taken in the morning. The dose can be increased to 120 mg, once a day.
Purpose: As a drug or adjunct therapy in patients with heart failure
- Dosage of 20 mg slow-release tablets, 2-3 times a day.
How to Take Isosorbide Mononitrate Correctly
Use isosorbide mononitrate as recommended by the doctor and don't forget to first read the instructions for use listed on the drug packaging. Do not increase or decrease your dose, and do not stop isosorbide mononitrate treatment without consulting your doctor first.
Take isosorbide mononitrate at the same time every day for optimal treatment. Isosorbide mononitrate should be taken in the morning after waking up. Swallow isosorbide mononitrate with the help of plain water, do not split or chew let alone crush the tablet.
If you forget to take isosorbide mononitrate tablets, take this drug immediately if the interval between the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
Do not stop using the drug without consulting your doctor first, even if your condition has improved. Stopping the drug suddenly can make the condition worse.
Store isosorbide mononitrate in a closed container at room temperature, in a dry place, and away from direct sunlight. Keep this medicine out of reach of children.
InteractionIsosorbide Mononitrate with Other Drugs
There are several drug interaction effects that can occur when isosorbide mononitrate is used with other drugs, namely:
- Increased risk of severe hypotension when used with riociguat or other drugs phosphodiesterase inhibitor type 5 (PDE5), such as avanafil, sildenafil, tadalafil, or vardenafil
- Enhanced effect of lowering blood pressure and slowing heart rate when used with drugs ACE inhibitor, such as captopril, enalapril, or lisinopril
- Increased levels of isosorbide mononitrate when used with clarithromycin, itraconazole, or ketoconazole
- Decreased effectiveness of isosorbide mononitrate when used with carbamazepine, phenobarbital, or phenytoin
Side Effects and Dangers of Isosorbide Mononitrate
The following are some of the side effects that can occur after taking isosorbide mononitrate:
- Headache
- Dizzy
- Nauseous
- Warmth in the neck, chest, or face (flush)
Check with a doctor if the complaints mentioned above do not subside or get worse. See your doctor right away if you have an allergic reaction to a drug or experience more serious side effects, such as:
- Huge headache
- Bluish color of lips, nails, or palms
- Irregular heartbeat, fast heartbeat (palpitations), or fast heart rate
- Chest pain that gets worse
- Feeling light-headed, dizzy, until you feel like passing out
