Streptokinase - Benefits, dosage and side effects

Streptokinase ismedicine to dissolve blood clots that form in blood vessels. This drug can be used in the treatment of heart attacks.

Streptokinase is a fibrinolytic or thrombolytic class of drugs. This drug works by activating plasminogen to form plasmin which will break down fibrin in blood clots. In addition to being used in heart attacks, this drug is also used to treat pulmonary embolism and pulmonary embolism deep vein thrombosis (DVT).

Streptokinase trademark: Fibrion

What is Streptokinase

groupPrescription drugs
BenefitDissolving blood clots in patients with heart attack, pulmonary embolism, anddeep vein thrombosis
Used byAdults and children
Streptokinase for pregnant and lactating womenCategory C:Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Streptokinase is not known whether it can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug formInject

WarningBefore Using Streptokinase

Streptokinase should only be used as prescribed by a doctor. There are several things you should pay attention to before using streptokinase, namely:

  • Do not use streptokinase if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you have or have ever had a blood disorder, blood clotting disorder, brain tumor, active bleeding, hypertension, diabetes, stroke, heart disease, endocarditis, kidney disease, lung disease, liver disease, pancreatitis, or hypotension.
  • Tell your doctor if you have or are currently suffering from an infection Streptococcus.
  • Tell your doctor if you have a history of injury or have recently had surgery, especially on the spine and brain.
  • Consult the use of streptokinase in elderly patients, because it can increase the risk of serious side effects.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • See your doctor right away if you have an allergic drug reaction, overdose, or serious side effect after taking streptokinase.

Dosage and Instructions for Use of Streptokinase

Streptokinase is available in the form of an injection that is given through a vein (intravenous / IV). The following is the distribution of streptokinase doses based on the patient's condition:

Condition: Acute myocardial infarction

  • Mature: 1.5 million units, as a single dose dissolved in an infusion and administered over 1 hour. This treatment is carried out as soon as symptoms of a heart attack appear.

Condition: Pulmonary embolism and deep vein thrombosis (DVT)

  • Mature:000 units, which are dissolved in the infusion and administered over 30 minutes. The maintenance dose is 100,000 units per hour, for 24–72 hours, depending on the patient's condition
  • Children: 2,500–4,000 units/kgBW, for 30 minutes. The follow-up dose is 500–1,000 units/kg per hour, for 3 days.

How to Use Streptokinase Correctly

Streptokinase should only be given by a doctor or by medical personnel under the supervision of a doctor. The dose of streptokinase will be given according to the patient's condition.

To get the best results, the use of streptokinase will be closely monitored by a doctor. During treatment with streptokinase, the doctor will monitor the patient's breathing, heart rate, and blood pressure.

Streptokinase can increase the risk of bleeding. To prevent severe bleeding, patients are advised not to move too much and to remain lying down until further instructions from the doctor.

InteractionStreptokinase with Other Drugs

There are several drug interaction effects that can occur when streptokinase is used with certain drugs, including:

  • Increased risk of bleeding if used with anticoagulant drugs, such as warfarin, or antiplatelet drugs, such as aspirin
  • Decreased effectiveness of streptokinase when used with antifibrinolytic drugs, such as aminocaproic acid

Streptokinase Side Effects and Dangers

Side effects that can occur after using streptokinase are:

  • Nausea, vomiting, or stomach pain
  • Fever or chills
  • Fatigue
  • Dizzy

Report it to the doctor or medical officer on duty if the above complaints do not subside or are actually getting worse.

Tell your doctor right away if you have an allergic reaction to your medication or experience more serious side effects, such as:

  • Severe dizziness until fainting
  • Confusion or blurred vision
  • Easy bruising
  • Vomiting blood or coughing up blood
  • Nosebleed
  • Difficult to breathe
  • Fast or slow heart rate
  • Bloody stools and urine
  • Red or purple spots on the skin
  • Back pain
  • Low blood pressure (hypotension)