Cefoperazone-sulbactam is an antibiotic used to treat various diseases caused by bacterial infections, such as respiratory tract infections, abdominal organ infections, meningitis, septicemia, urinary tract infections, or bone and joint infections.
Cefoperazone is a third generation cephalosporin antibiotic that inhibits the formation of bacterial cell walls, while sulbactam works by inhibiting the action of enzymes. beta lactamase, namely bacterial growth enzymes that can reduce the effect of cefoperazone. With the combination of these two drugs, their effectiveness in treating bacterial infections will increase.
Trademarks of cefoperazone-sulbactam:Baxcef, Cefoperazone/Sulbactam, Cefoperazone Sodium/Sulbactam Sodium, Cefratam, Ferotam, Fosular, Nubac, Simextam, Sulbacef, Zotam
What is Cefoperazone-Sulbactam
| group | Prescription drugs |
| Category | Cephalosporin antibiotics |
| Benefit | Treating bacterial infections |
| Used by | Adults and children |
| Cefoperazone-sulbactam for pregnant and lactating women | Category N:Not yet known. Cefoperazone-sulbactam is known to be absorbed into breast milk in small amounts. Breastfeeding women are advised to consult their doctor before using this drug. |
| Drug form | Inject |
Precautions Before Using Cefoperazone-Sulbactam
Before using cefoperazone-sulbactam, you need to pay attention to the following points:
- Tell your doctor about any allergies you have. Cefoperazone-subactam should not be used by someone who is allergic to this medicine, to penicillins, or to cephalosporin antibiotics, such as ceftazidime.
- Tell your doctor if you have or are currently suffering from liver disease, bile duct obstruction (biliary obstruction), kidney disease, or malabsorption syndrome.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
- See your doctor right away if you have an allergic reaction or overdose after using cefoperazone-sulbactam.
Dosage and Instructions for Use Cefoperazone-Sulbactam
The dose of cefoperazone-sulbactam can be different for each patient. This depends on the age and condition of each. However, in general the following is the dose of cefoperazone-sulbactam according to the patient's age:
Mature
- Mild to moderate bacterial infection is 1–2 grams per day, with a ratio of cefoperazone and sulbactam levels of 1:1.
- More serious infections, the maximum dose given is 4 grams per day, divided into 2 doses, with an interval of 12 hours per administration.
Children
- The dose given by the doctor is 0.02–0.04 gram/kgBW per day, with a ratio of cefoperazone and sulbactam levels of 1:1. The dose is divided into 2–4 doses, with a distance per administration of 6–12 hours.
- To treat serious bacterial infections, the maximum dose is 0.08 gram/kg body weight per day.
How to Use Cefoperazone-Sulbactam Correctly
Cefoperazone-sulbactam will be given by injection into a vein (intravenous/IV) or into a muscle (intramuscular/IM) by a doctor or medical staff under the supervision of a doctor. Follow the injection schedule given by the doctor for effective treatment.
While using this medicine, you may need to have regular kidney and liver function tests. Follow the schedule of examinations that have been set by the doctor for optimal treatment.
Cefoperazone-Sulbactam Interactions with Other Drugs
PThe use of cefoperazone-sulbactam with anticoagulant drugs, such as warfarin, increases the risk of bleeding. In addition, if used with alcoholic beverages, it can cause side effects such as burning sensation in the chest, neck, or face (flushing), sweating, headache, and tachycardia.
To prevent drug interactions, always consult your doctor if you plan to use cefoperazone-sulbactam with any medication, supplement or herbal product.
Side Effects and Dangers of Cefoperazone-Sulbactam
Some of the side effects that can occur after using cefoperazone-sulbactam are:
- Pain at the injection site
- Diarrhea
- Headache
- Fever or chills
- Nausea or vomiting
- Thrombocytopenia, which is a low number of platelets (platelets)
- Eosinophilia, which is a high number of one type of white blood cell (eosinophil)
Check with your doctor if the side effects mentioned above do not subside or are getting worse. You should also see a doctor immediately if you experience an allergic drug reaction after using cefoperazone-sulbactam.
