Daclatasvir - Benefits, dosage and side effects

Daclatasvir is an antiviral drug to treat hepatitis C. Daclatasvir should be used in combination with sofosbuvir. In addition to being used with sofosbuvir, daclatasvir can also be combined with other antiviral drugs, such as ribavirin.

Daclatasvir works by reducing the amount of hepatitis C virus in the body, so it can help the immune system to fight infection and help the liver recover. This drug cannot prevent transmission of hepatitis C.

Daclatasvir trademark: Dasvir, Mydekla, Natdac

What is Daclatasvir

groupPrescription drugs
CategoryAnti Virus
BenefitTreating hepatitis C
Consumed byMature
Daclatasvir for pregnant and lactating womenCategory X (if used with peginterferon alpha or ribavirin): Studies in experimental animals and humans have demonstrated fetal abnormalities or a risk to the fetus. Drugs in this category should not be used by women who are or may become pregnant.

It is not known whether Daclatasvir is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug formTablet

Precautions Before Taking Daclatasvir

Daclatasvir should only be used as prescribed by a doctor. Here are some things you need to pay attention to before taking daclatasvir:

  • Do not take daclatasvir if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you have or are currently suffering from hepatitis B, heart disease, or diabetes.
  • Tell your doctor if you have had a liver transplant procedure.
  • Tell your doctor if you are taking certain supplements, herbal products, or medications, such as rifampicin, carbamazepine, or St. John's wort.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy. The combination of daclatasvir with ribavirin should not be taken by pregnant women. Use effective contraception while on treatment with daclatasvir.
  • Carry out regular check-ups according to the schedule given by the doctor during treatment with daclatasvir.
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after taking daclatasvir.

Dosage and Use of Daclatasvir

The dose and duration of daclatasvir treatment will be determined by the doctor. In general, the dose of daclatasvir to treat hepatitis C genotype 1 or 3 in combination with other antiviral drugs is 60 mg, once daily. The duration of treatment may vary, depending on the genotype and the type of drug being taken.

How to Take Daclatasvir Correctly

Take daclatasvir as directed by your doctor and always read the instructions for use listed on the drug packaging. Do not reduce or increase the dose without consulting your doctor first.

Daclatasvir can be taken before or after meals. Use plain water to swallow the tablet.

If you forget to take daclatasvir, take it as soon as you remember. If it is near the time of your next dose, skip the missed dose and do not double the dose of daclatasvir.

Do not stop taking daclatasvir even if your condition improves. Stopping the drug suddenly can cause the infection to recur.

Store daclatasvir in a place away from direct sunlight. Keep this medicine out of reach of children.

Interactions of Daclatasvir with Other Drugs

There are several interactions that can occur if daclatasvir is taken with certain drugs, including:

  • Increased risk of severe liver damage if taken in combination with drugs containing asunaprevir
  • Decreased effectiveness of warfarin
  • Increased risk of bradycardia and fatal heart rhythm disturbances if taken with sofosbuvir or amiodarone
  • Decreased effectiveness of daclatasvir when used with phenytoin, carbamazepine, oxcarbazepine, phenobarbital, or rifampicin
  • Increased risk of developing hypoglycemia when used with antidiabetic drugs
  • Increased blood levels of daclatasavir when used with boceprevir, telaprevir, or atazanavir

In addition, when used together with St John's wort, daclatasvir levels in the blood can decrease, so the effectiveness of this drug in treating hepatitis C will also decrease.

Side Effects and Dangers of Daclatasvir

Some of the side effects that can occur after taking daclatasvir are:

  • Headache
  • Nauseous
  • Feel tired
  • Diarrhea

Check with a doctor if the complaints mentioned above do not go away or get worse. Call your doctor right away if you have an allergic reaction to your medication or experience more serious side effects, such as:

  • Slow or irregular heartbeat
  • Dizzy like you want to faint
  • Unusual tiredness
  • Hard to breathe
  • Chest pain
  • Memory disorder