Isoxsuprine is used to treat symptoms due to impaired blood flow, such as in Raynaud's disease, cerebral vascular insufficiency, or Buerger's disease.This drug can also sometimes be used to reduce contractions (tocolytics) in pregnancies at risk of preterm labor.
Isoxsuprine belongs to the class of vasodilator drugs. This drug works by dilating blood vessels, so blood can flow more smoothly. Isoxsuprine can only be used with a doctor's prescription.
Isoxsuprine trademark: Isoxsuprine Hydrochloride, Duvadilan, Hystolan, Proterine, Simduva, Tonotan, and Uterlax
What is Isoxsuprine
| group | Vasodilators |
| Category | Prescription drugs |
| Benefit | Treating symptoms due to impaired blood flow, such as Buerger's disease, cerebral vascular insufficiency, or Raynaud's disease |
| Used by | Mature |
| Isoxsuprine for pregnant and lactating women | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. It is not known whether isoxsuprine is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Shape | Tablets, injections |
Precautions Before Using Isoxsuprine
Isoxsuprine should not be used carelessly. There are several things you should pay attention to before starting treatment with isoxsuprine, namely:
- Do not use isoxsuprine if you are allergic to this drug.
- Tell your doctor if you have recently given birth or are experiencing abnormal bleeding. Isoxsuprine should not be used after delivery (postpartum) or if the patient is bleeding.
- Tell your doctor if you have or are currently experiencing bleeding, chest pain, glaucoma, heart attack, or stroke.
- Isoxsuprine can cause dizziness. Do not drive a vehicle, operate machinery, or perform activities that require alertness while taking isoxsuprine.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
- Tell your doctor if you are taking isoxsuprine before having any surgery, including dental surgery.
- See your doctor right away if you have an allergic reaction or overdose after taking isoxsuprine.
Isoxsuprine Dosage and Usage
Isoxsuprine should only be used as prescribed by a doctor. The dose of isoxsuprine can be different for each patient. The following are common doses of isoxsuprine:
Purpose: Relieves symptoms due to impaired blood circulation (flow)
- Tablets: 10–20 mg, 3-4 times daily.
- Injection: 10 mg, 3 times a day, given through a vein (IV/intravenous) or an artery (intra-arterial/IA).
Purpose:Premature birth
- Injectable: initial dose 0.2–0.3 mg per minute via IV, maximum 0.5 mg per minute. Continue until the contractions stop. This is followed by a muscle (intramuscular/IM) injection of 10 mg, 3 hours later.
How to Use Isoxsuprine Correctly
Follow the doctor's advice and read the information listed on the isoxsuprine package before starting to take it.
Isoxsuprine tablets can be taken before or after meals. Take isoxsuprine tablets with the help of a glass of water. Take this medicine at the same time every day. Do not stop taking isoxsuprine even if you feel better, unless advised by your doctor.
If you forget to take isoxsuprine, take it as soon as you remember if the break with the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
Especially for injectable isoxsuprine, the drug will be injected directly by a doctor or by a medical officer under the supervision of a doctor.
Your doctor may ask you to have blood tests or other medical tests while you are taking isoxsuprine. This is done to monitor the progress of therapy and the side effects that may be caused by the use of this drug.
Store isoxsuprine at room temperature. Do not store this medicine in a humid place or in direct sunlight. Keep isoxuprine out of the reach of children.
Isoxsuprine Interactions with Other Drugs
Isoxsuprine can cause drug interactions when used with other medicines. Here are some interactions between drugs that can occur:
- Enhances the effect of isoxsuprine when used with antihypertensive drugs
- Increased risk of hypotension if used with antidepressants, antipsychotic drugs, anticonvulsants, Parkinson's drugs, or tinazidine
Isoxsuprine Side Effects and Dangers
Some of the side effects that can occur after taking isoxsuprine are:
- Drowsiness
- Stomach ache
- Tired or limp
- Throw up
- Dizzy
- Headache
- Nausea or vomiting
Consult a doctor if the side effects above do not subside or get worse. Call your doctor right away if you have an allergic reaction to the drug, which is characterized by a rash on the skin, difficulty breathing, and swelling of the lips, or if you experience more serious side effects, such as:
- Chest pain
- Faint
- Hard to breathe
- Heavy dizziness
- Fast heart rate
