Cefoperazone - Benefits, dosage and side effects

Cefoperazone is an antibiotic drug used to treat bacterial infections. Cefoperazone is only available in injectable form. This medicine should only be used according to a doctor's prescription.

This third generation cephalosporin antibiotic drug works by interfering with the formation of bacterial cell walls, so that it will kill and inhibit the development of bacteria that cause infection. Cefoperazone can only treat bacterial infections and cannot treat viral infections, such as the flu.

Cefoperazone trademark: Biorazon, Cefoperazone, Cepraz, Cerozon, Ferzobat, Logafox, Sulbacef, Sulpefion, Stabixin-1

What is Cefoperazone

groupCephalosporin antibiotics
CategoryPrescription drugs
BenefitTreating bacterial infections
Used byMature
Cefoperazone for pregnant and lactating womenCategory B: Animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women.

Cefoperazone may be absorbed into breast milk. For breastfeeding mothers, do not use this medicine without consulting your doctor first.


Precautions Before Using Cefoperazone

Cefoperazone should only be used as prescribed by a doctor. Pay attention to the following points before using cefoperazone:

  • Tell your doctor about any allergies you have. Cefoperazone should not be given to patients who are allergic to this drug or to other cephalosporin antibiotics.
  • Tell the doctor if you suffer cystic fibrosis, alcoholism, malabsorption syndrome, malnutrition, blood clotting disorders, kidney disease, liver disease, or ulcerative colitis.
  • Tell your doctor if you are taking any other medications or supplements, including herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you plan to get vaccinated with live vaccines, while using cefoperazone, as this medicine may affect the effectiveness of the vaccine.
  • See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after using cefoperazone.

Dosage and Instructions for Use of Cefoperazone

The dose of cefoperazone used to treat bacterial infections in adults is 2–4 grams per day, divided into 2 doses. The dose can be increased up to 12 grams per day, divided into 2–4 doses.

Cefoperazone is given by injection into a muscle (intramuscularly/IM) or through a vein (intravenous/IV).

Apart from being in a single dosage form, cefoperazone can also be combined with sulbactam to increase the effectiveness of treatment.

How to Use Cefoperazonecorrectly

Cefoperazone will be given by a doctor or medical officer under the supervision of a doctor. Injections can be done IM/IV. Always follow the doctor's advice while undergoing treatment with this medicine.

During treatment with cefoperazone, your doctor may order you to have a medical exam or blood test to monitor your response to therapy and your condition.

Do not stop treatment without consulting your doctor first. Even if your symptoms are getting better, keep taking the treatment until it's finished.

Interactions of Cefoperazone with Other Drugs

There are several drug interaction effects that can occur when cefoperazone is used with other drugs, namely:

  • Increased risk of renal impairment when used with aminoglycosides or furosemide
  • Increased risk of bleeding if used with anticoagulants
  • Decreased effectiveness of live vaccines, such as cholera vaccines

Cefoperazone Side Effects and Dangers

Side effects that can occur after using cefoperazone are:

  • Cough
  • Diarrhea
  • Headache or dizziness
  • Easy bruising or nosebleeds
  • Shivering
  • Fever
  • Body feels weak or tired
  • Nauseous
  • Dark urine or bloody stools
  • Pain when urinating
  • Heart beat
  • Back pain

Consult a doctor if you experience the above side effects. Immediately see a doctor if there is an allergic reaction to the drug which can be characterized by swelling of the lips or eyelids, an itchy rash on the skin, or difficulty breathing.