Fondaparinux - Benefits, dosage and side effects

Fondaparinux is a drugto prevent and treat blood clots in deep veins or deep vein thrombosis(DVT). To increase the effectiveness of treatment, fondaparinux is usually combined with warfarin.

Fondaparinux is an anticoagulant that works by inhibiting the activity of factor Xa in the blood clotting process. That way, the formation of clots or blood clots in the deep veins can be prevented.

Blood clots in deep veins are at risk in someone who has recently had surgery on the abdomen or pelvis, as well as in people who have to lie down for a long time.

DVT that is not prevented and treated can lead to pulmonary embolism which is dangerous and life-threatening.

fondaparinux trademarks:Arixtra, Forixtra, Fondaparinux Sodium, Vasola

What is Fondaparinux

groupPrescription drugs
Category Factor Xa . inhibitor type anticoagulants
BenefitPrevent and treat deep vein thrombosis
Used byMature
Fondaparinux for pregnant and lactating womenCategory B: Studies in nonpregnant and lactating animal studies have shown a risk to the fetus, but there are no controlled studies in pregnant women.

It is not known whether Fondaparinux is absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.


WarningBefore Using Fondaparinux

Fondaparinux should only be used as prescribed by a doctor. There are several things that must be considered before using this drug, including:

  • Do not use fondaparinux if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you are taking nonsteroidal anti-inflammatory drugs (NSAIDs), other blood-thinning medications, such as rivaroxaban.
  • Tell your doctor if you have or have had kidney disease, liver disease, stomach ulcers, gastrointestinal bleeding, hypertension, heart infection, stroke, eye disease due to diabetes, colitis, blood clotting disorders, including thrombocytopenia.
  • Tell your doctor if you have recently had a spinal, epidural anesthetic procedure, or have recently had spinal, eye, or brain surgery.
  • Tell your doctor if you weigh less than 50 kg before using fondaparinux.
  • Do not consume alcoholic beverages while undergoing treatment with fondaparinux, because it can increase the risk of gastrointestinal bleeding.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
  • See your doctor right away if you experience an allergic drug reaction, serious side effect, or overdose after using fondaparinux.

Dosage and Instructions for Use Fondaparinux

Fondaparinux will be given by subcutaneous (under the skin/SC) injection by a doctor or medical personnel under the supervision of a doctor. The following is the division of fondaparinux doses based on the purpose of treatment:

Purpose: Treat deep vein thrombosis (DVT)

  • Adults weighing <50 kg: 5 mg, 1 time a day.
  • Adults weighing 50–100 kg: 7.5 mg, once a day.
  • Adults weighing >100 kg: 10 mg, 1 time a day. The duration of treatment is 5–9 days.

Purpose: Treating external venous thrombosis (superficial)

  • Mature: 2.5 mg, once daily, for 30–45 days.

Condition: Preventing DVT in patients undergoing abdominal surgery or orthopedic surgery

  • Mature: 2.5 mg, once a day. Treatment is started 6–8 hours after surgery. Treatment is carried out for 5–9 days. For patients at high risk of developing DVT, the length of treatment can be extended to 32 days after surgery.

MethodUsing Fondaparinux Correctly

Fondaparinux should only be injected by a doctor or medical officer under the supervision of a doctor. Follow the suggestions and recommendations during therapy using fondaparinux.

Fondaparinux can increase the risk of bleeding, always be careful when doing activities while undergoing therapy with fondaparinux. As much as possible, avoid collisions or activities that could cause injury.

InteractionFondaparinux with Other Drugs

Fondaparinux may increase the risk of bleeding when used with the following medicines:

  • Other anticoagulant drugs, such as warfarin, heparin, or apixaban
  • Antiplatelet drugs, such as cilostazol, clopidogrel, aspirin
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, ketolorac, or diclofenac
  • Fibrinolytic drugs, such as alteplase or streptokinase

In addition, the use of fondaparinux with products containing ginger, gingko biloba or ginseng, is also believed to increase the risk of bleeding. To prevent unwanted interactions, always tell your doctor about your medication history.

Fondaparinux Side Effects and Dangers

Side effects that may arise after taking fondaparinux are:

  • Insomnia or difficulty sleeping
  • Rash, itching, bruising, or swelling at the injection site
  • Dizziness or headache
  • Confusion
  • Nausea or vomiting
  • pale skin

Check with your doctor if the side effects above continue or get worse. You should also see a doctor immediately if you have an allergic reaction to your medication or if you have more serious side effects, such as:

  • Easy bruising or frequent nosebleeds
  • Heavy and prolonged menstruation (menorrhagia)
  • Dark urine
  • Yellowing of the skin and eyes (jaundice)
  • Heavy dizziness until fainting
  • Chest pain, fast or irregular heartbeat
  • Very heavy headache
  • Seizures
  • Weakness on one side of the body