Enoxaparin - Benefits, dosage and side effects

Enoxaparin is a drug to prevent or treat deep vein thrombosis. on the other hand, This drug can also be used to prevent complications from unstable angina. This drug is only available in injectable form and can only be given by a doctor or medical officer under the supervision of a doctor.

Enoxaparin works by reducing the activity of a protein that is responsible for clotting blood, thereby preventing the formation of blood clots. Blood clots are at risk in someone who has undergone abdominal surgery, knee surgery, pelvic surgery, or bed rest for a long time.

To prevent complications from unstable angina or as a treatment for coronary heart disease before PCI (percutaneous coronary intervention), enoxaparin will generally be used with aspirin.

Enoxaparin trademarks: Lovenox

What is Enoxaparin

groupPrescription drugs
BenefitPrevent and treat blood clots
Used byAdults and children
Enoxaparin for pregnant and lactating womenCategory B: Animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women.

It is not known whether Enoxaparin is absorbed into breast milk or not. For breastfeeding mothers, do not use this medicine without consulting your doctor first.

Drug formInject

Precautions Before Using Enoxaparin

There are a few things to consider before using enoxaparin:

  • Tell your doctor if you are allergic to enoxaparin, pork, heparin, or benzyl alcohol. This medicine should not be given to patients who are allergic to these drugs or food ingredients.
  • Tell your doctor if you are using an artificial heart valve or have recently had spinal anesthesia, brain surgery, spinal surgery, or eye surgery.
  • Tell your doctor if you have or have had liver disease, kidney disease, spinal cord injury, hemorrhagic stroke, thrombocytopenia, hemophilia, stroke, diabetic retinopathy, high blood pressure, endocarditis, stomach ulcers, or gastrointestinal bleeding
  • Be careful when using nail clippers, razors, or sharp objects, and avoid activities that increase the risk of impact or injury, during treatment with enoxaparin, as these drugs can increase the risk of bleeding.
  • Tell your doctor that you are taking enoxaparin if you plan to have surgery, such as dental surgery.
  • Tell your doctor if you are taking any other medications or supplements, including herbal products.
  • Tell your doctor if you have recently given birth, are pregnant, breastfeeding, or planning a pregnancy.
  • Do not consume alcoholic beverages because during treatment with enoxaparin, because it can increase the risk of gastrointestinal bleeding.
  • See your doctor right away if you have an allergic reaction, serious side effects, or overdose after taking enoxaparin.

Dosage and Instructions for Use of Enoxaparin

Enoxaparin can be given by injection under the skin (subcutan/SC). Enoxaparin injection will be given directly by a doctor or medical officer under the supervision of a doctor. The following are the doses of enoxaparin based on the intended use and age of the patient:

Purpose: Prevent deep vein thrombosis

  • Patient mature who underwent abdominal surgery: The dose is 40 mg, 2 hours before surgery.
  • Patient mature who underwent knee or hip replacement surgery: The dose is 30 mg every 12 hours, starting 12–24 hours after surgery. The duration of treatment is 10–35 days.
  • Children uwasted <2 months: 0.75 mg/kg, every 12 hours.
  • u childrenwaste 2 months: 0.5 mg/kg, every 12 hours.

Purpose: Treat deep vein thrombosis

  • Mature: 1 mg/kg, every 12 hours, or 1.5 mg/kg, once a day per day.
  • Children <2 months: 1.5 mg/kg, every 12 hours.
  • Children 2 months old: 1 mg/kg, every 12 hours.

Purpose: Prevent complications from unstable angina

  • Mature: 1 mg/kg, every 12 hours.

How to Use Enoxaparin Correctly

Enoxaparin will be given by a doctor or medical officer under the supervision of a doctor. The medicine will be injected into the deep layer of skin on the abdomen, about 5 cm from the navel, 1-2 times a day.

Always follow the doctor's advice during treatment. Do not scratch the injection site to prevent bruising.

During treatment with enoxaparin, the doctor will ask the patient to undergo regular medical examinations or blood tests. The goal is to monitor the response to therapy and the patient's overall condition.

Enoxaparin Interactions with Other Drugs

The risk of bleeding may increase if enoxaparin is used in combination with the following medicines or herbal supplements:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, or naproxen
  • Anticoagulants, such as warfarin or heparin
  • Antiplatelets, such as abciximab, clopidogrel, prasugrel, dipyridamole, or ticagrelor
  • Thrombolytics, such as alteplase
  • Certain herbal supplements, such as ginkgo biloba, garlic (garlic), ginseng, ginger

In addition, the risk of developing hyperkalemia may increase when enoxaparin is used with:

  • ACE inhibitors, such as benazepril, captopril, enalapril, or ramipril
  • Angiotensin IIreceptor blockers (ARB), such as candesartan or losartan
  • Potassium-sparing diuretics, such as amiloride or spironolactone
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Ciclosporin, tacrolimus, or trimethoprim

Enoxaparin Side Effects and Dangers

Common side effects after taking enoxaparin are:

  • Pain, swelling, bruising, or redness at the injection site
  • Fever
  • Stomach ache

Enoxaparin may increase the risk of bleeding. Immediately see a doctor if you experience the following side effects:

  • Severe headache
  • Dizziness or dizziness
  • Faint
  • Seizures
  • Nosebleeds or easy bruising
  • Menstrual bleeding more than usual
  • Numb
  • Bleeding in the wound that doesn't stop
  • Dark urine
  • Black stool
  • Swollen legs or ankles
  • Blurred vision
  • Body feels weak

In addition, you should also see a doctor immediately if you experience an allergic drug reaction after using enoxaparin.