Penicillin G procaine or procaine benzylpenicillin is an antibiotic drug to treat bacterial infections, such as anthrax, syphilis, or iinfection Streptococcus group A beta-hemolytic, or infection Staphylococcus.
Penicillin G procaine works by inhibiting the formation of bacterial cell walls that cause infection. Keep in mind, this drug can not be caused by viral infections, such as the flu. This drug is available in the form of an injection and should only be given according to a doctor's prescription.
Penicillin G procaine trademark: Benzathine Benzylpenicillin, Procaine Benzyl Penicillin, Procaine Penicillin G Meiji
What is Penicillin G Procaine
| group | Prescription drugs |
| Category | Penicillin antibiotics |
| Benefit | Treat anthrax, syphilis, infections Streptococcus group A beta-hemolytic, or infection Staphylococcus |
| Used by | Adults and children |
| Penicillin G procaine for pregnant and lactating women | Category B: Animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women. Penicillin G procaine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Inject |
Precautions Before Using Penicillin G Procaine
There are several things you should pay attention to before using penicillin G procaine, including:
- Tell your doctor about any allergies you have. Penicillin G procaine should not be given to patients who are allergic to this drug or to any other penicillin class of drugs.
- Tell your doctor if you have or have had asthma, heart disease, kidney disease, blood disorders, inflammatory bowel disease, or Brugada syndrome.
- Tell your doctor if you plan to get vaccinated with live vaccines while using penicillin G procaine, as this medicine may reduce the effectiveness of the vaccines used.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
- Tell your doctor right away if you have an allergic drug reaction, serious side effects, or overdose after using penicillin G procaine.
Dosage and Instructions for Use of Penicillin G Procaine
Penicillin G procaine will be injected by a doctor or medical officer under the supervision of a doctor by injection into the muscle (intramuscular / IM).
The dose of the drug given depends on the condition to be treated and the age of the patient. Here is the explanation:
Condition: Syphilis
- Mature: The dose for early-stage syphilis is 600 mg, once daily, for 10 days. The dose for advanced conditions is 600 mg, once daily, for 17 days.
Condition: Neurosyphilis
- Mature: The dose in combination with probenecid is 1,800–2,400 mg, once daily, for 17 days.
Condition: Congenital syphilis
- Children 2 years old: 50 mg/kg, once daily, for 10 days.
Condition: Skin anthrax
- Mature: 600–1,000 mg, once daily.
Condition: Treatment and prevention of anthrax
- Mature:200 mg, every 12 hours, for 60 days.
- Children: 25 mg/kg, every 12 hours, for 60 days.
Condition: Infection Streptococcus group A beta-hemolytic, infection Staphylococcus
- Mature: 1,500 mg per day, for 2–5 days. The 4th and 5th doses will be given according to the need and severity of the disease.
How to Use Penicillin G Procaine Correctly
Penicillin G procaine will be injected directly by a doctor or medical officer under the supervision of a doctor.
Follow the schedule of injections of drugs given by the doctor. Do not stop taking medication without consulting your doctor first. Follow all the recommendations and advice given by the doctor while undergoing treatment with penicillin G procaine so that the effectiveness of the treatment is maximized.
If you are taking penicillin G procaine long term, you may be asked to have regular blood tests. Make sure you take the inspection as scheduled.
Interactions of Penicillin G Procaine with Other Drugs
The following are some of the effects of interactions that may occur if penicillin G procaine is used in combination with other medicines:
- Increased levels of methotrexate in the blood which can cause side effects, such as vomiting, canker sores, and decreased blood cell levels
- Decreased levels of penicillin G procaine when used with tetracycline or doxycycline
- Increased risk of methemoglobinemia when used with prilocaine
- Decreased effectiveness of live vaccines, such as BCG vaccine or cholera vaccine
- Increased risk of bleeding if used with blood-thinning medications, such as warfarin
- Decreased effectiveness of birth control pills
Side Effects and Dangers Penicillin G Procaine
Side effects that can arise after using penicillin G procaine include:
- Nauseous
- Throw up
- Pain, swelling, and redness at the injection site
See your doctor right away if you have an allergic reaction to a drug or experience more serious side effects, such as:
- Heart palpitations, fast heartbeat, or irregular heartbeat
- Unusual tiredness
- Confused, depressed, or hallucinating
- Tingling or numbness in the hands or feet
- Severe diarrhea or bloody diarrhea
