Clomifene - Benefits, dosage and side effects

Clomifene is a drug to treat infertility or infertility in women who have ovulation disorders. One of the causes of infertility in woman is a disorder in the process of ovulation or the release of a mature egg from the ovary into the fallopian tube, so that pregnancy is difficult.

Clomiphene or clomiphene is a class of drugs selective estrogen receptor modulator (SERM). This drug will trigger an increase in the production and amount of hormones that are responsible for stimulating the ovaries to produce eggs. This drug will also stimulate the maturation and release of eggs (ovulation).

Clomifene trademark: Bifertil, Blesifen, Clomifene Citrate, Clomifil, Clovertil, Dipthen, Fervula, Fertin, Fertion, Genoclom, GP-Fertil, Provula, Profertil, Pinfetil.

What is Clomiphene

groupPrescription drugs
CategorySynthetic hormone class selective estrogen receptor modulator
BenefitOvercoming infertility or infertility due to disruption of ovulation
Consumed byMature

Clomifene for pregnant and lactating women

Category X: Studies in experimental animals and humans have demonstrated fetal abnormalities or a risk to the fetus.

This medicine should not be used by women who are or may become pregnant.

It is not known whether clomiphene can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Drug formTablet

Precautions Before Taking Clomifene

Clomifene should only be taken according to a doctor's prescription. There are several things that must be considered before using this drug, including:

  • Tell your doctor about any allergies you have. Clomifene should not be taken by patients who are allergic to this drug.
  • Tell your doctor if you have or are experiencing unexplained vaginal bleeding, PCOS, liver disease, fibroids, endometriosis, adrenal gland disease, brain tumor, or high triglycerides.
  • Tell your doctor if your period is late after treatment with clomiphene, as clomiphene should be discontinued if you become pregnant.
  • Tell your doctor if you are taking certain medications, supplements, or herbal products.
  • Do not drive a vehicle and do activities that require alertness after taking clomiphene, as this medicine can cause dizziness.
  • Tell your doctor right away if you have an allergic reaction to any medication, serious side effects, or an overdose after taking clomiphene.

Dosage and Rules for Use of Clomifene

Clomifene is given to treat infertility due to ovulation disorders. This drug will be given to women of childbearing age who are planning a pregnancy.

In general, the dose of clomifene for this condition is 50 mg, once daily. The drug can be started on the 5th day of the menstrual cycle, when there is no bleeding.

If ovulation does not occur, the drug can be repeated at a dose of 100 mg, once daily, for 5 days, starting 30 days after the first dose. Dosage can be repeated up to a maximum of 3 times.

How to Take Clomifene Correctly

Follow the doctor's recommendations and read the information listed on the drug packaging label before consuming clomiphene. Do not increase or decrease the dose without consulting your doctor first.

Clomifene tablets can be taken with or without food. Swallow the tablet whole with a glass of water. Do not split, crush, crush or chew the medicine.

Take clomiphene at the same time every day for maximum treatment. If you forget to take it, take this medicine immediately if the interval with the next schedule of use is not too close. If it is close, ignore it and do not double the dose.

Clomifene needs to be taken on the 5th day of menstruation or as directed by a doctor. About 5-10 days after taking clomiphene is expected to occur ovulation. In order to increase the chances of getting pregnant, the doctor will recommend you and your partner to have sex at the time of ovulation.

Store clomiphene in tightly closed containers in a cool room. Do not store in a humid place and protect this medicine from direct sunlight. Keep this medicine out of reach of children.

Clomifene Interactions with Other Drugs

Always tell your doctor if you are taking certain medications, supplements, or herbal products. The effects of drug interactions that can occur if clomiphene is used with other drugs are as follows:

  • Increased risk of developing inflammation of the pancreas (pancreatitis) when used with bexarotene
  • Increased risk of side effects, such as blood clot formation, stroke, when used with ospemifene

Clomifene Side Effects and Dangers

There are several side effects that can arise after consuming clomiphene, namely:

  • Warmth in the face, neck, or chest (flush)
  • Pain or discomfort in the breast
  • Vomiting or stomach pain
  • Spotting or vaginal bleeding outside the menstrual cycle.

Check with your doctor if the side effects mentioned above do not subside or are getting worse. Immediately see a doctor if an allergic reaction occurs to a drug or serious side effects occur, such as:

  • Visual disturbances that can be in the form of blurred vision, eye pain, or the appearance of black dots or spots when viewing
  • Swollen stomach, severe abdominal pain, nausea and vomiting that does not go away, or diarrhea
  • Chest pain, swelling or pain in the legs, shortness of breath, fast or irregular heartbeat
  • Mental and mood disorders (mood)